Guillaume Canaud obtained a 2016 ERC Proof of Concept Grant entitled: CureTheCloves. Briefly, the Congenital Lipomatous Overgrowth, Vascular Malformations, Epidermal Nevi, Scoliosis/Skeletal and Spinal (CLOVES) syndrome is a genetic disorder due to a gain of function mutation of the PIK3CA in a mosaic fashion. This rare condition is associated with severe deformation and poor survival. We identified a new drug able to dramatically improve the outcome of patients with this rare disease. The purpose of the Proof of Concept grant is to better understand the molecular effect of this drug.
Guillaume Canaud obtained a 2015 ERC Starting Grant entitled: Podocyte Adaptation Proliferation and Ageing Study (PAPA_Study). Briefly, this project is focused on the biology of the podocyte during chronic kidney disease progression, one of the major public health challenges of the 21st Century. This work will combine complementary in vivo and in vitro approaches, experimental models of chronic kidney disease on genetically modified mice, as well as the use of a very innovative and new technology of bioengineering to explore the molecular and structural changes of the podocytes during kidney diseases.