Recent works

Targeted therapy in patients with PIK3CA-related overgrowth syndrome

Venot Q, Blanc T, Hadj Rabia S, Berteloot L, Ladraa S, Duong JP, Blanc E,  Johnson SC, Hoguin C, Boccara O, Sarnacki S, Boddaert N, Pannier S, Martinez F, Magassa S, Yamaguchi J, Knebelmann B, Merville P, Grenier N, Joly D, Cormier-Daire V, Michot C, Bole-Feysot C, Picard A, Soupre V, Lyonnet S, Sadoine J, Slimani L, Chaussain C, Laroche-Raynaud C, Guibaud L,  Broissand C, Amiel, Legendre L, Terzi F, Canaud G. Molecular targeted therapy in patients with PIK3CA-related overgrowth syndrome. Nature 2018 with commentary

Stress-induced Akt2 activation is crucial for podocyte maintenance in chronic kidney disease

Canaud G, Bienaimé F, Treins C, Viau A, Nguyen C, Berissi S, Giannakakis K, Muda Onetti A, Friedlander G, Legendre C, Pende M, Terzi F. Stress-induced Akt2 activation is crucial for podocyte maintenance in chronic kidney disease. Nat Med. 2013 Oct;19(10):1288-96, with commentary Oct;19(10):1212-3

Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome

Canaud G, Bienaimé F, Tabarin F, Bataillon G, Seilhean D, Noel LH, Dragon-Durey MA, Snanoudj R, Friedlander G, Halbwachs-Mecarelli L, Legendre C, Terzi F. Inhibition of the mTORC Pathway in the Antiphospholipid Syndrome. N Engl J Med. 2014 Jul 24;371(4):303-312, with commentary Jul 24;371(4):369-371)

Costimulation (B7-1) blockade does not improve post transplant nephrotic syndrome from recurrent FSGS.

Delville M, Baye E, Durrbach A, Audard V, Kofman T, Braun L, Olagne J, Nguyen C, Deschênes G, Moulin B, Delahousse M, Kesler-Roussey G, Beaudreuil S, Martinez F, Rabant M, Grimbert P, Gallazzini M, Terzi F, Legendre C, Canaud G. Costimulation (B7-1) blockade does not improve post transplant nephrotic syndrome from recurrent FSGS. J Am Soc Nephrol. 2015 Dec.

The costimulatory receptor B7-1 is not induced in injured podocytes

Baye E, Gallazzini M, Delville M, Legendre C, Terzi F, Canaud G. The costimulatory receptor B7-1 is not induced in injured podocytes. Kidney Int. 2016 Aug 12

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